Genes influenced by food; epigenetic switches tun genes and off.

geneA new study, published in the journal Nature Microbiology, has revealed how genes may influence the food that is consumed. Genes influence , but nutrients may also influence genes by being available to cells.

“Cellular plays a far more dynamic role in the cells than we previously thought,” said Dr, Markus Ralser at the University of Cambridge and the Francis Crick Institute, London Ralser.

“Nearly all of a cell’s genes are influenced by changes to the nutrients they have access to. In fact, in many cases the effects were so strong, that changing a cell’s metabolic profile could make some of its genes behave in a completely different manner.

“The classical view is that genes control how nutrients are broken down into important molecules, but we’ve shown that the opposite is true, too: how the nutrients break down affects how our genes behave.”

The researchers used a yeast model to examine the activity of genes and related to nutrients. Genes can be regulated by other genes or regions of DNA or by epigenetic modifiers acting like switches turning genes on and off.

The different levels of were manipulated in yeast cells. An investigation was conducted as to how this impacted on the behavior of genes and molecules they produced. Almost nine out of ten genes and their products were affected by changes in cellular .

Source

Alam, MT et al. The metabolic background is a global player in Saccharomyces gene expression epistasis. Nature Microbiology; 1 Feb. DOI: 10.1038/nmicrobiol.2015.30

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s