Vitamin D reduces risk of Chrohn’s disease.

vitd1A new study published by the United European Gastroenterology journal has revealed that supplementation with may impact on Chrohn’s disease.

Crohn’s disease(CD) is defined as a lifelong chronic relapsing and remitting condition, with inflammation of the . The condition is defined by abdominal pain, and fatigue and incidences of Chrohn’s disease occur in 10 cases per 100,000 population per year.

Supplementation with may impact on the intestinal barrier associated with Chrohn’s disease and lowers the intestinal barrier dysfunction. The participants consisted of 27 patients in remission who took part in a double-blind randomized placebo-controlled study with a 2000 IU/day supplementation or placebo for 3 months.

The findings determined that patients who consumed supplementation were more likely to maintain their intestinal permeability, whereas this deteriorated in the placebo group.

“This is the first reporting of effects of supplementation on intestinal permeability and antimicrobial peptide measures in a CD cohort. Whilst the data requires further confirmation, it broadly supports evidence from previous experimental studies that suggest a role for in maintaining intestinal barrier.”

“This is an exciting development in the treatment of Crohn’s disease and we welcome anything new that could potentially help patients with this debilitating condition”, said Dr Charles Murray of the Royal Free Hospital.


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