A new study, by the China Medical University Hospital n Taichung, Taiwan, has specified that a synthetic form of vanilla extract, known as vanillin, may help to prevent or treat psoriasis. Approximately, 7.5 million people are affected in the United States.
Psoriasis is triggered by an overactive immune system, which accelerates the production of new skin cells and causes inflammation.
The researchers induced psoriatic skin inflammation in groups of mice by placing a compound called imiquimod on their skin. The mice were orally given daily doses (0, 1, 5, 10, 50 or 100 milligrams/kilograms of body weight) of vanillin for seven days. Mice treated with 50- or 100-milligram/kilograms of body weight doses had reduced psoriatic symptoms compared to those receiving smaller or no doses of vanillin. In all mice treated with vanillin, IL-17 and IL-23 protein levels were decreased.
The findings were reported in the Journal of Agricultural and Food Chemistry and researchers determined that administering higher doses of vanillin to mouse models of psoriasis for 1 week led to a significant reduction in skin inflammation, compared with psoriatis mice that did not receive the compound or had lower doses.
Vanillin targets the inflammatory proteins that trigger the condition and may not only reduce the symptoms but prevents the symptoms.
Oral Administration of Vanillin Improves Imiquimod-Induced Psoriatic Skin Inflammation in Mice. Journal of Agriculture and Food Chemistry.
J. Agric. Food Chem., 2017, 65 (47), pp 10233–10242